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by Dr. C.H. Weaver M.D. 10/2020

Celiac disease is considered a disease of the digestive system as well as an autoimmune disease.

It causes damage to the small intestine, which interferes with the absorption of nutrients from food and triggers an abnormal immune response to foods containing gluten. The disease affects people worldwide, including more than 2 million people in the United States.

Gluten, which is a protein found in wheat, rye, and barely, may also be present in products such as medicines, vitamins, lip balms, and many processed foods. Because people who have celiac disease cannot tolerate gluten, it’s very important that they learn to carefully read labels and identify foods that may contain gluten.

How does a person with celiac disease react to eating gluten?

Gluten triggers an abnormal immune, or autoimmune, response among people with celiac disease. This abnormal activity involves the villi, which are small, fingerlike protrusions that line the small intestine. The villi are supposed to allow nutrients from food to be absorbed into the bloodstream, but in celiac disease, the immune system destroys or damages the villi when gluten is ingested. As a result, it’s impossible for a person with celiac disease who eats gluten-containing foods to be properly nourished, as the digestive system cannot absorb nutrients in food.

What are the symptoms of Celiac Disease?

Celiac disease runs in families, so those with a genetic risk should be particularly aware of its symptoms. But because the disease may be diagnosed late in life or misdiagnosed, not having an immediate relative who’s been diagnosed doesn’t mean that you’re not at risk—celiac disease may run in your family but may not have been detected yet. Anyone who experiences the following symptoms should consult their healthcare provider about celiac disease.

Symptoms of celiac disease in adults:

  • Fatigue
  • Bone or joint pain
  • Iron-deficiency anemia with no known cause
  • Arthritis
  • Bone loss or osteoporosis
  • Depression or anxiety
  • Tingling numbness in hands and feet
  • Seizures
  • Missed menstrual periods
  • Infertility or recurrent miscarriage
  • Itchy skin rash

As you can tell from the list above, the symptoms of celiac disease of varied, as is the age when symptoms appear. The reason for this is not fully understood but may be related to factors including the length of time a person was breastfed, the age at which a person began eating foods containing gluten, the amount of gluten-containing foods consumed, and age at diagnosis (though some people have celiac disease long before it’s diagnosed).

It’s also true that not everyone with celiac disease will develop symptoms. Even without symptoms, however, the disease can still cause serious health complications related to malnutrition. Anyone who has a close family member with celiac disease should consider screening (see more about screening in “How is it diagnosed?”).

Celiac disease also affects children, though symptoms tend to be different from those of adults—namely, children are more likely than adults to have digestive symptoms. Celiac disease is a particular concern among children because they need to properly absorb nutrients from food to ensure healthy growth and development. Children may experience the following symptoms:

  • Abdominal bloating and pain
  • Chronic diarrhea
  • Vomiting
  • Constipation
  • Pale, foul-smelling, or fatty stool
  • Weight loss

How is Celiac Disease diagnosed?

Celiac disease can be difficult to diagnose because its symptoms may be confused with other diseases, such as irritable bowel syndrome, chronic fatigue syndrome, and inflammatory bowel disease. Fortunately, however, effective screening tests are increasingly available and doctors are becoming more familiar with symptoms. Here, some of the screening tests currently being used are described.

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Can blood tests detect Celiac Disease?

Because celiac disease involves an autoimmune response, people with the disease have a higher blood level of proteins that react against the body’s own cells or tissues when they eat gluten. Called autoantibodies, these proteins can be measured with a blood test. Because autoantibody levels will be raised by eating gluten, it’s important to continue to eat gluten before the test. Otherwise, test results may not indicate celiac disease even if it is present.

Intestinal Biopsy can Confirm Celiac Disease

When a blood test indicates celiac disease, the next step is to confirm the diagnosis with an intestinal biopsy. This involves the removal of tiny tissue samples from the small intestine, which the doctor inspects for damage to the villi. An intestinal biopsy is performed using an endoscope, a tube passed through the mouth and stomach and into the small intestine.

Dermatitis Herpetiformis

Dermatitis herpetiformis (DH) is the “itchy skin rash” listed under symptoms of celiac disease. DH is an intensely itchy irritation that can also cause blisters and usually occurs on the elbows, knees, and buttocks. It affects 15 to 25 percent of people with celiac disease; these people may have no digestive symptoms.

To diagnose DH, a doctor will use a blood test and a skin biopsy. Because celiac with DH is both an intestinal disease and a skin disease, it’s treated with two approaches: 1) a gluten-free diet to manage intestinal symptoms and 2) antibiotics to treat the skin disease (skin symptoms will also improve with a gluten-free diet).

What Does other research show?

Untreated celiac disease may lead to earlier menopause.

Women with untreated celiac may go through menopause earlier and have a higher risk of some pregnancy complications than women without the disease or women who have been diagnosed and treated, according to the results of a recent study.(1)

Celiac disease is an autoimmune condition that affects the digestive system. Individuals with celiac disease are allergic to a protein called gluten, which is found in wheat, barley, and rye. In individuals with the disease, eating foods with gluten causes damage to the small intestine and prevents it from absorbing nutrients. Following a strict gluten-free diet is the only way to manage celiac disease. Unfortunately, celiac disease can go undiagnosed for a long time because the symptoms can be vague and misunderstood and can range from diarrhea to fatigue to skin rash and even depression.

Women suffering from celiac disease tend to have nutrient deficiencies and lower estrogen levels, which could explain the earlier onset of menopause. In order to examine this relationship, researchers conducted a study involving103 postmenopausal women: 45 celiac-free women; 33 women with celiac disease that wasn’t diagnosed until after menopause; and 25 women with celiac disease who had been diagnosed and followed a gluten-free diet for at least 10 years prior to menopause.

The researchers found that, on average, women with untreated celiac disease went through menopause about three years earlier than their counterparts, which means they have a shorter “fertile life span.” Furthermore, they had a higher rate of miscarriages and premature births.

The researchers concluded that diagnosing celiac disease early might help delay early menopause—possibly because it could help prevent some of the nutritional and hormonal deficiencies associated with celiac disease.

The association is important because when women are diagnosed with celiac disease early and follow a strict gluten-free diet, they do not appear to go through menopause any earlier than their celiac-free counterparts. Recognizing the signs and symptoms of celiac disease is important. Some red flags may include unexplained anemia, diarrhea, and fatigue.

In contrast, women who experience early menopause and have symptoms of celiac disease may want to get tested for the disease; while it can’t help delay menopause, it can help address the disease and improve quality of life during their postmenopausal years.


  1. Santonicola A, Iovino P, Cappello C, et al. From menarche to menopause: The fertile lifespan of celiac women. Menopause. Published early online June 3, 2011: doi: 10.1097/gme.0b013e3182188421